Labels:text | screenshot | black and white | black | font | document OCR: Whereas normal intracellular cleavage usually proinsulin into insulin and C-peptide is in enters almost complete and very little proinsu substantial the circulation, in most B-cell tumours, amounts of intact proinsulin forms and ed into the partially-split forms (Fig. 20.15) are relea circulation where they are detected as proinsulin immunoreactive insulin. In some cases t, or even and partially-split forms account for mo asurable in all, of the insulin immunoreactivity me peripheral venous plasma. the highest Insulinomas are usually associated with reactive and most inappropriate plasma immun insulin levels
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